Durchsicht von Akten


Hier eine Auswahl unserer Publikationen (aus 35 Manuskripten der letzten fünf Jahre):

1.       Therapeutic opportunities of the IL-22-IL-22R1 system. Sabat R, Ouyang W, Wolk K. Nat Rev Drug Discov. 2013 Dec 31;13(1):21-38. IF 33,078


2.       Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice. Kumari S, Bonnet MC, Ulvmar MH, Wolk K, Karagianni N, Witte E, Uthoff-Hachenberg C, Renauld JC, Kollias G, Toftgard R, Sabat R 1, Pasparakis M 1, Haase I 1. Immunity. 2013 Nov 14;39(5):899-911. IF 19,795


3.       IL-29 is produced by T(H)17 cells and mediates the cutaneous antiviral competence in psoriasis. Wolk K, Witte K, Witte E, Raftery M, Kokolakis G, Philipp S, Schönrich G, Warszawska K, Kirsch S, Prösch S, Sterry W, Volk HD, Sabat R. Sci Transl Med. 2013 Sep 25;5(204):204ra129. IF 10,757


4.       CD44 variant isoforms control experimental autoimmune encephalomyelitis by affecting the lifespan of the pathogenic T cells. Ghazi-Visser L, Laman JD, Nagel S, van Meurs M, van Riel D, Tzankov A, Frank S, Adams H, Wolk K, Terracciano L, Melief MJ, Sabat R, Günthert U. FASEB J. 2013 Sep;27(9):3683-701. IF 5,704


5.       Immunological changes in psoriasis patients under long-term treatment with fumaric acid esters: risk of Kaposi sarcoma occurrence? Philipp S, Kokolakis G, Hund M, Witte E, Witte K, Kunz S, Roewert HJ, Sterry W, Sabat R. Eur J Dermatol. 2013 Jun 1;23(3):339-43. IF 1,756


6.       Depression is a frequent co-morbidity in patients with acne inversa. Kurek A, Johanne Peters EM, Sabat R, Sterry W, Schneider-Burrus S. J Dtsch Dermatol Ges. 2013 Aug;11(8):743-50. IF 1,403


7.       New insights into fumaric acid esters (Fumaderm ®):results of the 2nd Expert Workshops. Mrowietz U, Altmeyer P, Augustin M, Boehncke WH, Bonnekoh B, Frambach Y, Gambichler T, Ghoreschi K, Hertl M, Hund AC, Jacobi A, Kuhn A, Ludwig RJ, Luger T, Martin SF, Merk H, Norgauer J, Reich K, Rostami-Yazdi M, Sabat R, Schäkel K, Scharffetter-Kochanek K, Schön MP, Scola N, Sticherling M, Thaci D, Wilsmann-Theis D, Viehweg A, Wozel G, Zouboulis CC, Neureither M. J Dtsch Dermatol Ges. 2012 Dec;10 Suppl 8:1-15. IF 1,403


8.       Profound disturbances of sexual health in patients with acne inversa. Kurek A, Peters EM, Chanwangpong A, Sabat R, Sterry W, Schneider-Burrus S. J Am Acad Dermatol. 2012 Sep;67(3):422-8. IF 4,906


9.       Increased prevalence of metabolic syndrome in patients with acne inversa. Sabat R, Chanwangpong A, Schneider-Burrus S, Metternich D, Kokolakis G, Kurek A, Philipp S, Uribe D, Wolk K, Sterry W. PLoS One. 2012;7(2):e31810. IF 3,730


10.   Interleukin-22: implications for liver ischemia-reperfusion injury. Chestovich PJ, Uchida Y, Chang W, Ajalat M, Lassman C, Sabat R, Busuttil RW, Kupiec-Weglinski JW. Transplantation. 2012 Mar 15;93(5):485-92. IF 3,781


11.   Dual Role of IL-22 in allergic airway inflammation and its cross-talk with IL-17A. Besnard AG, Sabat R, Dumoutier L, Renauld JC, Willart M, Lambrecht B, Teixeira MM, Charron S, Fick L, Erard F, Warszawska K, Wolk K, Quesniaux V, Ryffel B, Togbe D. Am J Respir Crit Care Med. 2011 May 1;183(9):1153-63. IF 11,080


12.   Research in practice: IL-22 and IL-20: significance for epithelial homeostasis and psoriasis pathogenesis. Sabat R, Wolk K. J Dtsch Dermatol Ges. 2011 Jul;9(7):518-23. IF 1,471


13.   Deficiency of IL-22 contributes to a chronic inflammatory disease: pathogenetic mechanisms in acne inversa. Wolk K, Warszawska K, Hoeflich C, Witte E, Schneider-Burrus S, Witte K, Kunz S, Buss A, Roewert HJ, Krause M, Lukowsky A, Volk HD, Sterry W, Sabat R. J Immunol. 2011 Jan 15;186(2):1228-39. IF 5,788


14.   IL-10 family of cytokines. Sabat R. Cytokine Growth Factor Rev. 2010 Oct;21(5):315-24. IF 8,239


15.   Administration of IL-23 engages innate and adaptive immune mechanisms during fungal infection. Kleinschek MA, Müller U, Schütze N, Sabat R, Straubinger RK, Blumenschein WM, McClanahan T, Kastelein RA, Alber G. Int Immunol. 2010 Feb;22(2):81-90. IF 3,301


16.   Biology of interleukin-10. Sabat R, Grütz G, Warszawska K, Kirsch S, Witte E, Wolk K, Geginat J. Cytokine Growth Factor Rev. 2010 Oct;21(5):331-44. IF 8,239


17.   Interleukin-22: a cytokine produced by T, NK and NKT cell subsets, with importance in the innate immune defense and tissue protection. Witte E, Witte K, Warszawska K, Sabat R 1, Wolk K 1. Cytokine Growth Factor Rev. 2010 Oct;21(5):365-79. IF 8,239


18.   Interleukin-28 and interleukin-29: novel regulators of skin biology. Wolk K, Witte K, Sabat R. J Interferon Cytokine Res. 2010 Aug;30(8):617-28. IF 2,576


19.   IL-28A, IL-28B, and IL-29: promising cytokines with type I interferon-like properties. Witte K, Witte E, Sabat R 1, Wolk K 1. Cytokine Growth Factor Rev. 2010 Aug;21(4):237-51. IF 8,239


20.   Biology of interleukin-22. Wolk K, Witte E, Witte K, Warszawska K, Sabat R. Semin Immunopathol. 2010 Mar;32(1):17-31. IF 5,216


21.   Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17. Muñoz M, Heimesaat MM, Danker K, Struck D, Lohmann U, Plickert R, Bereswill S, Fischer A, Dunay IR, Wolk K, Loddenkemper C, Krell HW, Libert C, Lund LR, Frey O, Hölscher C, Iwakura Y, Ghilardi N, Ouyang W, Kamradt T, Sabat R, Liesenfeld O. J Exp Med. 2009 Dec 21;206(13):3047-59. IF 14,505


22.   The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis. Wolk K, Witte E, Warszawska K, Schulze-Tanzil G, Witte K, Philipp S, Kunz S, Döcke WD, Asadullah K, Volk HD, Sterry W, Sabat R. Eur J Immunol. 2009 Dec;39(12):3570-81. IF 5,179


23.   Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines. Witte K, Gruetz G, Volk HD, Looman AC, Asadullah K, Sterry W, Sabat R, Wolk K. Genes Immun. 2009 Dec;10(8):702-14. IF 4,222


24.   Expression of tolerance associated gene-1, a mitochondrial protein inhibiting T cell activation, can be used to predict response to immune modulating therapies. Keeren K, Friedrich M, Gebuhr I, Philipp S, Sabat R, Sterry W, Brandt C, Meisel C, Grütz G, Volk HD, Sawitzki B. J Immunol. 2009 Sep 15;183(6):4077-87. IF 5,646


25.   Interleukin-10 and articular cartilage: experimental therapeutical approaches in cartilage disorders. Schulze-Tanzil G, Zreiqat H, Sabat R, Kohl B, Halder A, Müller RD, John T. Curr Gene Ther. 2009 Aug;9(4):306-15. IF 4,852


26.   IL-10 protects monocytes and macrophages from complement-mediated lysis. Koch N, Jung M, Sabat R, Krätzschmar J, Döcke WD, Asadullah K, Volk HD, Grütz G. J Leukoc Biol. 2009 Jul;86(1):155-66. IF 4,403


27.   Antibody epitope mapping using SPOT peptide arrays. Reineke U, Sabat R. Methods Mol Biol. 2009;524:145-67.    IF 0,000


28.   Differential IL-23 requirement for IL-22 and IL-17A production during innate immunity against Salmonella enterica serovar Enteritidis. Siegemund S, Schütze N, Schulz S, Wolk K, Nasilowska K, Straubinger RK, Sabat R, Alber G. Int Immunol. 2009 May;21(5):555-65. IF 3,403


29.   Osteopontin as two-sided mediator of intestinal inflammation. Heilmann K, Hoffmann U, Witte E, Loddenkemper C, Sina C, Schreiber S, Hayford C, Holzlöhner P, Wolk K, Tchatchou E, Moos V, Zeitz M, Sabat R, Günthert U, Wittig BM. J Cell Mol Med. 2009 Jun;13(6):1162-74. IF 5,228


30.   IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-gamma are not. Wolk K, Haugen HS, Xu W, Witte E, Waggie K, Anderson M, Vom Baur E, Witte K, Warszawska K, Philipp S, Johnson-Leger C, Volk HD, Sterry W, Sabat R. J Mol Med. 2009 May;87(5):523-36. IF 5,004


31.   Protective immunity to systemic infection with attenuated Salmonella enterica serovar enteritidis in the absence of IL-12 is associated with IL-23-dependent IL-22, but not IL-17. Schulz SM, Köhler G, Schütze N, Knauer J, Straubinger RK, Chackerian AA, Witte E, Wolk K, Sabat R, Iwakura Y, Holscher C, Müller U, Kastelein RA, Alber G. J Immunol. 2008 Dec 1;181(11):7891-901. IF 6,000


32.   A simple assay to measure phagocytosis of live bacteria. Bicker H, Höflich C, Wolk K, Vogt K, Volk HD, Sabat R. Clin Chem. 2008 May;54(5):911-5. IF 5,579


33.   Maturing dendritic cells are an important source of IL-29 and IL-20 that may cooperatively increase the innate immunity of keratinocytes. Wolk K, Witte K, Witte E, Proesch S, Schulze-Tanzil G, Nasilowska K, Thilo J, Asadullah K, Sterry W, Volk HD, Sabat R. J Leukoc Biol. 2008 May;83(5):1181-93. IF 4,605


34.   Formation of reactive oxygen species in lung alveolar cells: effect of vitamin E deficiency. Sabat R, Guthmann F, Rüstow B. Lung. 2008 Mar-Apr;186(2):115-22. IF 1,495


35.   Long-term interleukin-10 presence induces the development of a novel, monocyte-derived cell type. Schoenbein C, Docke WD, Wolk K, Belbe G, Hoflich C, Jung M, Grutz G, Sterry W, Volk HD, Asadullah K, Sabat R. Clin Exp Immunol. 2008 Feb;151(2):306-16. IF 2,853


36.  Effect of immunisation against angiotensin II with CYT006-AngQb on ambulatory blood pressure: a double-blind, randomised, placebo-controlled phase IIa study. Tissot AC, Maurer P, Nussberger J, Sabat R, Pfister T, Ignatenko S, Volk HD, Stocker H, Müller P, Jennings GT, Wagner F, Bachmann MF. Lancet. 2008 Mar 8;371(9615):821-7. IF 28,409


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